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About us | People Contact | Sitemap | Help Research | Education | Publications ETH Zurich - D-HEST - Energy Metabolism Laboratory Welcome Key Publications Ristow M Nature Medicine, 20, 709-711 (2014) » Weimer S, Priebs J, et al. Nature Commun, 5, e3563 (2014) » Schmeisser K, Mansfeld J, et al., Nat Chem Biol, 9, 693-700 (2013) » Zarse K, et al., Cell Metab, 15, 451-465 (2012) » Ristow M, et al., Proc Natl Acad Sci USA, 106:8865-70 (2009) » Schulz TJ, et al., Cell Metab, 6: 280-293 (2007) » Useful Links D-HESTETHZ People SearchPubMed Article FinderGoogle Scholar Article FinderVideo Introduction to C.elegans ExperimentsSciencegateway Hyperlink CollectionLeo Dictionary Enzyme Code ListingEnzyme InhibitorsC. elegans Knockout ConsortiumWormbaseAddgene plasmid collectionWebcutter 2.0Jackson Mouse Genome InformationThe Art of Grant WritingGordon Research ConferencesKeystone SymposiaSwiss Nutrition Society Welcome to the Energy Metabolism Lab. Being located at the ETH Zurich since January 2013, we are pursuing our research on the biochemical and molecular basis of longevity regulation to provide novel therapeutic options to prevent and cure age-related diseases like obesity, diabetes and cancer. We are interested in the biochemical and molecular basis of longevity — in particular the role played by mitochondria in lifespan regulation. Contrary to the widely reiterated Free Radical Theory of Aging, we have repeatedly shown that the health-promoting effects associated with low caloric intake, physical exercise and other lifespan-extending interventions may be due to increased formation of Reactive Oxygen Species (ROS) within the mitochondria, causing a vaccination-like adaptive response that culminates in increased stress resistance and extended longevity, a process a. k. a. mitochondrial hormesis or mitohormesis. We work with the roundworm C. elegans and mammalian model organisms, as well as occasionally in humans. Find us on Wichtiger Hinweis: Diese Website wird in älteren Versionen von Netscape ohne graphische Elemente dargestellt. Die Funktionalität der Website ist aber trotzdem gewährleistet. Wenn Sie diese Website regelmässig benutzen, empfehlen wir Ihnen, auf Ihrem Computer einen aktuellen Browser zu installieren. Weitere Informationen finden Sie auf folgender Seite. Important Note: The content in this site is accessible to any browser or Internet device, however, some graphics will display correctly only in the newer versions of Netscape. To get the most out of our site we suggest you upgrade to a newer browser. More information © 2014 ETH Zurich | Imprint | Disclaimer | 17 July 2013
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