网站综合信息 jci.org
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- JCI - Welcome
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- 域名信息
- 域名年龄:28年1个月18天 注册日期:1996年04月04日 到期时间:
邮箱:sysadmin 电话:+1.17342226050
注册商:GoDaddy.com, LLC
- 服务器空间
- IP:45.79.158.159 同IP网站2个 详情
地址:美国
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域名流量Alexa排名
域名注册Whois信息
jci.org
域名年龄: 28年1个月18天注册时间: 1996-04-04
注 册 商: GoDaddy.com, LLC
注册邮箱: sysadmin
联系电话: +1.17342226050
获取时间: 2016年02月23日 22:16:58
Domain Name: JCI.ORG
Domain ID: D2795739-LROR
WHOIS Server:
Referral URL: http://www.godaddy.com
Updated Date: 2013-12-10T15:32:02Z
Creation Date: 1996-04-04T05:00:00Z
Registry Expiry Date: 2017-04-05T05:00:00Z
Sponsoring Registrar: GoDaddy.com, LLC
Sponsoring Registrar IANA ID: 146
Domain Status: clientDeleteProhibited https://www.icann.org/epp#clientDeleteProhibited
Domain Status: clientRenewProhibited https://www.icann.org/epp#clientRenewProhibited
Domain Status: clientTransferProhibited https://www.icann.org/epp#clientTransferProhibited
Domain Status: clientUpdateProhibited https://www.icann.org/epp#clientUpdateProhibited
Registrant ID: CR34517954
Registrant Name: John Hawley
Registrant Organization: American Society for Clinical Investigation
Registrant Street: 2015 Manchester Road
Registrant City: Ann Arbor
Registrant State/Province: Michigan
Registrant Postal Code: 48104
Registrant Country: US
Registrant Phone: +1.17342226050
Registrant Phone Ext:
Registrant Fax: +1.17342226058
Registrant Fax Ext:
Registrant Email: sysadmin
Admin ID: CR34517958
Admin Name: John Hawley
Admin Organization: American Society for Clinical Investigation
Admin Street: 2015 Manchester Road
Admin City: Ann Arbor
Admin State/Province: Michigan
Admin Postal Code: 48104
Admin Country: US
Admin Phone: +1.17342226050
Admin Phone Ext:
Admin Fax: +1.17342226058
Admin Fax Ext:
Admin Email: sysadmin
Tech ID: CR34517956
Tech Name: Shawn Pyle
Tech Organization: American Society for Clinical Investigation
Tech Street: 2015 Manchester Road
Tech City: Ann Arbor
Tech State/Province: Michigan
Tech Postal Code: 48104
Tech Country: US
Tech Phone: +1.17342226050
Tech Phone Ext:
Tech Fax: +1.17342226058
Tech Fax Ext:
Tech Email: sysadmin
Name Server: NS-1027.AWSDNS-00.ORG
Name Server: NS-1755.AWSDNS-27.CO.UK
Name Server: NS-799.AWSDNS-35.NET
Name Server: NS-480.AWSDNS-60.COM
DNSSEC: unsigned
>>> Last update of WHOIS database: 2016-02-22T17:12:40Z <<<
"For more information on Whois status codes, please visit https://icann.org/epp"
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网站头文件(HTTP Header)
HTTP/1.1 200 OK 访问时间:2017年01月10日 08:09:54 服务器:Apache/2.4.16 (CentOS) 缓存控制:max-age=0, private,必须更新 网站XSS保护:1; mode=block X-Request-Id: 83622a82-6b96-41cf-901b-45bec266d3c7 X-Frame-Options: SAMEORIGIN X-Runtime: 0.340434 X-Content-Type-Options: nosniff 语言环境:Phusion Passenger Enterprise 5.0.28 设置Cookie:jci_content_session_id=8ff134430a60dd9d15e959432229f783; path=/; HttpOnly 网页标记:"fb7464750adf364a6f4aa56fdf489d1f-gzip" Status: 200 OK 动作:Accept-Encoding Content-Encoding: gzip 文件大小:18223 Keep-Alive: timeout=5, max=100 连接:Keep-Alive 类型:text/html; charset=utf-8 网站编码:utf-8
同IP网站(同服务器)
网站首页快照(纯文字版)
抓取时间:2017年01月10日 08:02:37
网址:http://jci.org/
标题:JCI - Welcome
关键字:
描述:
主体:
网址:http://jci.org/
标题:JCI - Welcome
关键字:
描述:
主体:
Go toJCI InsightAboutEditorsConsulting EditorsFor authorsAlertsAdvertiseSubscribeContactCurrent IssuePast IssuesBy specialtyCardiologyGastroenterologyImmunologyMetabolismNephrologyNeuroscienceOncologyPulmonologyVascular biologyAll...VideosConversations with Giants in MedicineAuthor's TakesReviewsReviewsView all reviews...Review SeriesMetabolism and Inflammation (Jan 2017)Hypoxia and Inflammation (Oct 2016)Extracellular Vesicles (Apr 2016)HIV (Feb 2016)Cancer Immunotherapy (Sep 2015)Autoimmunity (Jun 2015)Enteric Nervous System (Mar 2015)View all review series...CollectionsRecently publishedCommentariesEditorialsOpinionScientific Show StoppersTop read articlesClinical MedicineJCI This MonthCurrent issuePast issuesThe Journal of Clinical InvestigationAboutEditorsConsulting EditorsFor authorsCurrent issuePast issuesBy specialtySubscribeAlertsAdvertiseContactVideosConversations with Giants in MedicineAuthor's TakesCollectionsRecently publishedBrief ReportsTechnical AdvancesCommentariesEditorialsHindsightReview seriesReviewsThe Attending PhysicianFirst Author PerspectivesScientific Show StoppersTop read articlesRecently published- MoreSelective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell responsePatients with leukemia who receive a T cell–depleted allogeneic stem cell graft followed by postponed donor lymphocyte infusion (DLI) can experience graft-versus-leukemia (GVL) reactivity, with a...Published January 9, 2017Categories:Research ArticleHematologyTransplantationSelective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell responseTextPDFAbstractPatients with leukemia who receive a T cell–depleted allogeneic stem cell graft followed by postponed donor lymphocyte infusion (DLI) can experience graft-versus-leukemia (GVL) reactivity, with a lower risk of graft-versus-host disease (GVHD). Here, we have investigated the magnitude, diversity, and specificity of alloreactive CD8 T cells in patients who developed GVL reactivity after DLI in the absence or presence of GVHD. We observed a lower magnitude and diversity of CD8 T cells for minor histocompatibility antigens (MiHAs) in patients with selective GVL reactivity without GVHD. Furthermore, we demonstrated that MiHA-specific T cell clones from patients with selective GVL reactivity showed lower reactivity against nonhematopoietic cells, even when pretreated with inflammatory cytokines. Expression analysis of MiHA-encoding genes showed that similar types of antigens were recognized in both patient groups, but in patients who developed GVHD, T cell reactivity was skewed to target broadly expressed MiHAs. As an inflammatory environment can render nonhematopoietic cells susceptible to T cell recognition, prevention of such circumstances favors induction of selective GVL reactivity without development of GVHD.AuthorsCornelis A.M. van Bergen, Simone A.P. van Luxemburg-Heijs, Liesbeth C. de Wreede, Matthijs Eefting, Peter A. von d
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